![]() To minimize ventilator-induced lung injury the concept of lung-protective ventilation was introduced comprising the limitation of P plat, reduction of V T and optimization of positive end-expiratory pressure (PEEP) –. ![]() Liable factors inducing lung injury are high plateau pressures (P plat), high tidal volumes (V T) and cyclic opening and closing of alveoli (tidal recruitment). Dreyfuss and coworkers comprehensively showed the relationship between mechanical ventilation and pathologic lung tissue changes. It is well known that mechanical ventilation leads to lung injury. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. All other authors declare that no competing interests exist. Professor Frerichs received reimbursement of travel costs and speaking fees from Viasys Healthcare, Swisstom, and Draeger Medical, respectively. Elke received a restricted research grant from Cardinal Health for experimental studies unrelated to this work. Zick received partial financial funding from Novalung to perform the study. No additional external funding was received for this study.Ĭompeting interests: Dr. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.įunding: The study was partially supported by Novalung, Hechingen, Germany ( The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Received: NovemAccepted: JPublished: August 22, 2013Ĭopyright: © 2013 Zick et al. ![]() PLoS ONE 8(8):Įditor: Rory Edward Morty, University of Giessen Lung Center, Germany (2013) Effect of PEEP and Tidal Volume on Ventilation Distribution and End-Expiratory Lung Volume: A Prospective Experimental Animal and Pilot Clinical Study. Citation: Zick G, Elke G, Becher T, Schädler D, Pulletz S, Freitag-Wolf S, et al.
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